How does chimeric antigen receptor (CAR) T-cell therapy cause B-cell aplasia?

Updated: May 04, 2018
  • Author: Sameh Gaballa, MD, MS; Chief Editor: Emmanuel C Besa, MD  more...
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Answer

Answer

B-cell aplasia occurs when anti-CD19 CAR T-cells kill normal B lymphocytes that express CD19. These patients are typically are at high risk of developing infections, because of their hypogammaglobulinemia. However, this can be treated with intravenous immunoglobulin (IVIG) replacement therapy. [27]


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