How does chimeric antigen receptor (CAR) T-cell therapy cause B-cell aplasia?

Updated: Dec 17, 2020
  • Author: Sameh Gaballa, MD, MS; Chief Editor: Emmanuel C Besa, MD  more...
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Answer

Answer

B-cell aplasia occurs when anti-CD19 CAR T cells inadvertently damage normal B-lymphocytes that express CD19. Patients are typically at high risk of developing infections because of their hypogammaglobulinemia. However, this can be treated with intravenous immunoglobulin (IVIG) replacement therapy. [41]  While B-cell aplasia can cause long-term hypogammaglobulinemia, some patients will reconstitute their B-cells and restore their immunoglobulin levels without requiring life-long IVIG. [42]


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