What are adverse effects of chimeric antigen receptor (CAR) T-cell therapy?

Updated: May 04, 2018
  • Author: Sameh Gaballa, MD, MS; Chief Editor: Emmanuel C Besa, MD  more...
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Answer

Answer

The most serious adverse effects of CAR T-cell therapy, which can be fatal, include cytokine release syndrome (CRS), neurological toxicity, and B-cell aplasia. Researchers at the University of Texas MD Anderson Cancer Center in Houston have developed guidelines for helping clinicians recognize and manage the unique acute toxicities associated with CAR T-cell therapy, including CRS and CAR T-cell–related encephalopathy syndrome (CRES). [20, 21]


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