What is the global prevalence Zika virus infection?

Answer

The global prevalence of Zika virus infection has not been widely reported owing to asymptomatic clinical course, clinical resemblance to other infection with other flaviviruses (dengue, chikungunya), and difficulty in confirming diagnosis.

Based on sporadic case reports, entomological surveys, and seroprevalence surveys, Zika virus infection had been reported in various hosts, including humans, primates, and mosquitoes, in 14 countries across Africa, Asia, and Oceania, as of 2014.^[9]The prevalence of Zika virus infection in Uganda was 6.1% in 1952 among a population of 99 residents.^[10]The prevalence of Zika virus infection was 7.1% in Java, Indonesia, from 1977-1978 among patients who were hospitalized for fever.^[11]Since Zika virus was first isolated in 1947, the disease has spread outside of Africa, mainly into Southeast Asia. Until 2007, sporadic cases of Zika virus illness in humans were reported. In 2007, Yap Island in Micronesia reported an outbreak of Zika virus infection transmitted via Aedes hensilli.^[5]Subsequently, in 2013 and 2014, epidemics of Zika virus infection occurred in French Polynesia, New Caledonia, Cook Islands, and Easter Islands.^[12]

In May 2015, Brazil reported the first outbreak of Zika virus infection in the Americas. The Brazil Ministry of Health estimated around 440,000-1,300,000 suspected cases of Zika virus infection in December 2015.^[13]Aedes aegypti and Aedes albopictus were recognized as vectors for transmission of Zika virus. Since then, the infection has spread rapidly to several other countries, becoming a pandemic. The association of Zika virus infection with Guillain-Barré syndrome (GBS) and congenital birth defects (particularly microcephaly) amid the ongoing outbreak of Zika virus infection in Brazil is still under investigation.^{[13, 14]}

In March 2016, the WHO reported that Zika virus was actively circulating in 38 countries and territories, 12 of which have reported an increase in GBS cases or laboratory evidence of Zika virus among patients with GBS.^[15]

As of June 2016, a total of 591 laboratory-confirmed travel-associated Zika virus infections have been reported in the United States, with none acquired via local vector-borne transmission. Eleven cases have been transmitted sexually, and one case of associated Guillain-Barré syndrome has been reported.^[16]US territories such as Puerto Rico and the US Virgin Islands have 935 laboratory-confirmed local cases of Zika virus infection, and 4 cases have been attributed to travel.^[16]Five cases of associated Guillain-Barré syndrome have been reported. See the images below.

Laboratory-confirmed Zika virus disease cases reported to ArboNET by state or territory — United States, 2015–2016 (as of May 25, 2016). Courtesy of the CDC.

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All countries and territories with active Zika virus transmission. Courtesy of the CDC.

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Bennett JE, Dolin R, Blaser MJ. Mandell, Douglas, and Bennett's Principles and Practice of Infectious Diseases. 8th ed. Philadelphia, PA: Elsevier/Saunders; 2015. Vol 2:
Petersen E, Wilson ME, Touch S, McCloskey B, Mwaba P, Bates M, et al. Rapid Spread of Zika Virus in The Americas - Implications for Public Health Preparedness for Mass Gatherings at the 2016 Brazil Olympic Games. Int J Infect Dis. 2016 Feb 4. 44:11-15. [Medline].
Gardner T, Mason J. U.S. officials warn Zika 'scarier' than initially thought. Reuters. Available at http://www.reuters.com/article/us-health-zika-whitehouse-idUSKCN0X825A. April 11, 2016; Accessed: April 12, 2016.
Besnard M, Lastere S, Teissier A, Cao-Lormeau V, Musso D. Evidence of perinatal transmission of Zika virus, French Polynesia, December 2013 and February 2014. Euro Surveill. 2014 Apr 3. 19 (13):[Medline].
Duffy MR, Chen TH, Hancock WT, Powers AM, Kool JL, Lanciotti RS, et al. Zika virus outbreak on Yap Island, Federated States of Micronesia. N Engl J Med. 2009 Jun 11. 360 (24):2536-43. [Medline].
Marchette NJ, Garcia R, Rudnick A. Isolation of Zika virus from Aedes aegypti mosquitoes in Malaysia. Am J Trop Med Hyg. 1969 May. 18 (3):411-5. [Medline].
Foy BD, Kobylinski KC, Chilson Foy JL, Blitvich BJ, Travassos da Rosa A, Haddow AD, et al. Probable non-vector-borne transmission of Zika virus, Colorado, USA. Emerg Infect Dis. 2011 May. 17 (5):880-2. [Medline].
Sirohi D, Chen Z, Sun L, Klose T, Pierson TC, Rossmann MG, et al. The 3.8 Å resolution cryo-EM structure of Zika virus. Science. 2016 Mar 31. [Medline].
Ioos S, Mallet HP, Leparc Goffart I, Gauthier V, Cardoso T, Herida M. Current Zika virus epidemiology and recent epidemics. Med Mal Infect. 2014 Jul. 44 (7):302-7. [Medline].
Dick GW. Epidemiological notes on some viruses isolated in Uganda; Yellow fever, Rift Valley fever, Bwamba fever, West Nile, Mengo, Semliki forest, Bunyamwera, Ntaya, Uganda S and Zika viruses. Trans R Soc Trop Med Hyg. 1953 Jan. 47 (1):13-48. [Medline].
Olson JG, Ksiazek TG, Suhandiman, Triwibowo. Zika virus, a cause of fever in Central Java, Indonesia. Trans R Soc Trop Med Hyg. 1981. 75 (3):389-93. [Medline].
Roth A, Mercier A, Lepers C, Hoy D, Duituturaga S, Benyon E, et al. Concurrent outbreaks of dengue, chikungunya and Zika virus infections - an unprecedented epidemic wave of mosquito-borne viruses in the Pacific 2012-2014. Euro Surveill. 2014 Oct 16. 19 (41):[Medline].
European Centre for Disease Prevention and Control, Stockholm. Zika virus disease epidemic: potential association with microcephaly and Guillain-Barré syndrome (first update). Available at http://ecdc.europa.eu/en/publications/Publications/rapid-risk-assessment-zika-virus-first-update-jan-2016.pdf. January 21, 2016;
Mlakar J, Korva M, Tul N, Popović M, Poljšak-Prijatelj M, Mraz J, et al. Zika Virus Associated with Microcephaly. N Engl J Med. 2016 Feb 10. [Medline].
World Health Organization. WHO Director-General briefs the media on the Zika situation. World Health Organization. Available at http://www.who.int/mediacentre/news/statements/2016/zika-update-3-16/en/. March 22, 2016; Accessed: April 12, 2016.
Centers for Disease Control and Prevention. Zika virus disease in the United States, 2015–2016. Centers for Disease Control and Prevention. Available at http://www.cdc.gov/zika/geo/united-states.html. May 25, 2016; Accessed: June 1, 2016.
[Guideline] World Health Organization. Breastfeeding in the context of Zika virus: Interim guidance. World Health Organization. Available at http://apps.who.int/iris/bitstream/10665/204473/1/WHO_ZIKV_MOC_16.5_eng.pdf. February 25, 2016; Accessed: March 18, 2016.
[Guideline] World Health Organization. Assessment of infants with microcephaly in the context of Zika virus: Interim guidance. World Health Organization. Available at http://apps.who.int/iris/bitstream/10665/204475/1/WHO_ZIKV_MOC_16.3_eng.pdf?ua=1. March 4, 2016; Accessed: March 18, 2016.
Mécharles S, Herrmann C, Poullain P, Tran TH, Deschamps N, Mathon G, et al. Acute myelitis due to Zika virus infection. Lancet. 2016 Mar 3. [Medline].
[Guideline] CDC. Interim Guidance for Zika Virus Testing of Urine - United States, 2016. MMWR Morb Mortal Wkly Rep. 2016 May 13. 65 (18):474. [Medline]. [Full Text].
[Guideline] Petersen EE, Staples JE, Meaney-Delman D, Fischer M, Ellington SR, Callaghan WM, et al. Interim Guidelines for Pregnant Women During a Zika Virus Outbreak - United States, 2016. MMWR Morb Mortal Wkly Rep. 2016 Jan 22. 65 (2):30-3. [Medline]. [Full Text].
[Guideline] World Health Organization. Identification and management of Guillain-Barré syndrome in the context of Zika virus: Interim guidance. World Health Organization. Available at http://apps.who.int/iris/bitstream/10665/204474/1/WHO_ZIKV_MOC_16.4_eng.pdf?ua=1. February 25, 2016; Accessed: March 18, 2016.
[Guideline] Rabe IB, Staples JE, Villanueva J, Hummel KB, Johnson JA, Rose L, et al. Interim Guidance for Interpretation of Zika Virus Antibody Test Results. MMWR Morb Mortal Wkly Rep. 2016 Jun 3. 65 (21):543-6. [Medline]. [Full Text].
[Guideline] Brooks JT, Friedman A, Kachur RE, LaFlam M, Peters PJ, Jamieson DJ. Update: Interim Guidance for Prevention of Sexual Transmission of Zika Virus - United States, July 2016. MMWR Morb Mortal Wkly Rep. 2016 Jul 25. 65 (29):745-7. [Medline]. [Full Text].
Marano G, Pupella S, Vaglio S, Liumbruno GM, Grazzini G. Zika virus and the never-ending story of emerging pathogens and transfusion medicine. Blood Transfus. 2015 Nov 5. 1-6. [Medline].
[Guideline] Petersen EE, Polen KN, Meaney-Delman D, et al. Update: Interim Guidance for Health Care Providers Caring for Women of Reproductive Age with Possible Zika Virus Exposure - United States, 2016. MMWR Morb Mortal Wkly Rep. 2016 Apr 1. 65 (12):315-22. [Medline]. [Full Text].
Cetron M. Revision to CDC's Zika Travel Notices: Minimal Likelihood for Mosquito-Borne Zika Virus Transmission at Elevations Above 2,000 Meters. MMWR Morb Mortal Wkly Rep. 2016 Mar 18. 65 (10):267-8. [Medline].
National Institutes of Health. Testing of investigational inactivated Zika vaccine in humans begins. National Institutes of Health. Available at https://www.nih.gov/news-events/news-releases/testing-investigational-inactivated-zika-vaccine-humans-begins. November 7, 2016; Accessed: November 9, 2016.
The White House. FACT SHEET: Preparing for and Responding to the Zika Virus at Home and Abroad. The White House. Available at https://www.whitehouse.gov/the-press-office/2016/02/08/fact-sheet-preparing-and-responding-zika-virus-home-and-abroad. February 8, 2016;
[Guideline] Centers for Disease Control and Prevention. Guidelines for Travelers Visiting Friends and Family in Areas with Chikungunya, Dengue, or Zika. Centers for Disease Control and Prevention. Available at http://wwwnc.cdc.gov/travel/page/travelers-vfr-chikungunya-dengue-zika. August 08, 2016; Accessed: August 27, 2016.
[Guideline] U.S. Food and Drug Administration. Revised Recommendations for Reducing the Risk of Zika Virus Transmission by Blood and Blood Components. U.S. Food and Drug Administration. Available at http://www.fda.gov/downloads/BiologicsBloodVaccines/GuidanceComplianceRegulatoryInformation/Guidances/Blood/UCM518213.pdf. August 26, 2016; Accessed: August 27, 2016.
[Guideline] Oduyebo T, Polen KD, Walke HT, et al. Update: Interim Guidance for Health Care Providers Caring for Pregnant Women with Possible Zika Virus Exposure — United States (Including U.S. Territories), July 2017. Morbidity and Mortality Weekly Report (MMWR). Available at https://www.cdc.gov/mmwr/volumes/66/wr/mm6629e1.htm. July 24, 2017; Accessed: July 24, 2017.
[Guideline] Adebanjo T, Godfred-Cato S, Viens L, Fischer M, Staples JE, Kuhnert-Tallman W, et al. Update: Interim Guidance for the Diagnosis, Evaluation, and Management of Infants with Possible Congenital Zika Virus Infection - United States, October 2017. MMWR Morb Mortal Wkly Rep. 2017 Oct 20. 66 (41):1089-1099. [Medline].
United States Environmental Protection Agency. EPA Registers the Wolbachia ZAP Strain in Live Male Asian Tiger Mosquitoes. EPA. Available at https://www.epa.gov/pesticides/epa-registers-wolbachia-zap-strain-live-male-asian-tiger-mosquitoes. November 7, 2017; Accessed: November 9, 2017.
Kelly JC. New Guidance Issued by CDC on Zika IgM Testing in Pregnancy. Medscape. Available at http://www.medscape.com/viewarticle/879684. May 8, 2017; Accessed: June 1, 2017.
CDC Health Network. Prolonged IgM Antibody Response in People Infected with Zika Virus: Implications for Interpreting Serologic Testing Results for Pregnant Women. Centers for Disease Control and Prevention. Available at https://emergency.cdc.gov/han/han00402.asp. May 5, 2017;
Gourinat AC, O'Connor O, Calvez E, Goarant C, Dupont-Rouzeyrol M. Detection of Zika virus in urine. Emerg Infect Dis. 2015 Jan. 21 (1):84-6. [Medline].
Oehler E, Watrin L, Larre P, Leparc-Goffart I, Lastere S, Valour F, et al. Zika virus infection complicated by Guillain-Barre syndrome--case report, French Polynesia, December 2013. Euro Surveill. 2014 Mar 6. 19 (9):[Medline].
Fontes BM. Zika virus-related hypertensive iridocyclitis. Arq Bras Oftalmol. 2016 Feb. 79 (1):63. [Medline].
Ventura CV, Maia M, Ventura BV, Linden VV, Araújo EB, Ramos RC, et al. Ophthalmological findings in infants with microcephaly and presumable intra-uterus Zika virus infection. Arq Bras Oftalmol. 2016 Feb. 79 (1):1-3. [Medline].
Butler D. Zika virus: Brazil's surge in small-headed babies questioned by report. Nature. 2016 Feb 4. 530 (7588):13-4. [Medline].
Schuler-Faccini L, Ribeiro EM, Feitosa IM, Horovitz DD, Cavalcanti DP, Pessoa A, et al. Possible Association Between Zika Virus Infection and Microcephaly - Brazil, 2015. MMWR Morb Mortal Wkly Rep. 2016 Jan 29. 65 (3):59-62. [Medline].

Media Gallery

Testing algorithm for pregnant women with history of travel to areas with active Zika virus transmission. Courtesy of the Centers for Disease Control and Prevention (CDC).
Rash in a patient with Zika virus infection. Courtesy of Carolina O Barbosa, MD, and Antonio C Bandeira, MD, Salvador, Brazil.
Rash in a patient with Zika virus infection. Courtesy of Carolina O Barbosa, MD, and Antonio C Bandeira, MD, Salvador, Brazil.
Rash in a patient with Zika virus infection. Courtesy of Carolina O Barbosa, MD, and Antonio C Bandeira, MD, Salvador, Brazil.
Laboratory-confirmed Zika virus disease cases reported to ArboNET by state or territory — United States, 2015–2016 (as of May 25, 2016). Courtesy of the CDC.
All countries and territories with active Zika virus transmission. Courtesy of the CDC.

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