Which hosts are susceptible to Zika virus?

Updated: Jun 30, 2021
  • Author: Bhagyashri D Navalkele, MD, MBBS; Chief Editor: Michael Stuart Bronze, MD  more...
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Answer

Zika virus is well-adapted to grow in various hosts, ranging from arthropods to vertebrates. Zika virus has tropism for various tissues in the human body such as skin, blood, placenta cells, testes, retinal cells, neural stem cells and neuroprogenitor cells. Zika virus also infects monocytes, facilitating passage across blood brain and placental barriers. Host cells invaded by Zika virus undergo cellular appoptosis, necrosis, and death. Thus, Zika virus affecting neuronal progenitor cells affects neuronal growth resulting in fetal brain abnormalities and placental insufficiency resulting in fetal loss. [10]   


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