Which medications in the drug class Antivirals, Influenza are used in the treatment of Avian Influenza (Bird Flu)?

Updated: Feb 12, 2020
  • Author: Nicholas John Bennett, MBBCh, PhD, MA(Cantab), FAAP; Chief Editor: Michael Stuart Bronze, MD  more...
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Answer

Antivirals, Influenza

Agents that inhibit neuraminidase activity may be of benefit.

Oseltamivir (Tamiflu)

Inhibits neuraminidase, which is a glycoprotein on the surface of influenza virus that destroys an infected cell's receptor for viral hemagglutinin. By inhibiting viral neuraminidase, decreases release of viruses from infected cells and thus viral spread. Effective to treat influenza A or B. For hospitalized patients and outpatients with severe, complicated, or progressive illness (eg, development of pneumonia), treatment with oral or enterically administered oseltamivir is recommended. Start within 40 h of symptom onset. Available as cap (75 mg, 45 mg, 30 mg) and oral susp.

Zanamivir (Relenza)

Inhibitor of neuraminidase, which is a glycoprotein on the surface of the influenza virus that destroys the infected cell's receptor for viral hemagglutinin. By inhibiting viral neuraminidase, release of viruses from infected cells and viral spread are decreased. Effective against both influenza A and B. Consider use for outpatients without underlying asthma or COPD. Administer by inhalation via Diskhaler oral inhalation device. Circular foil discs containing 5-mg blisters of drug are inserted into supplied inhalation device. IV zanamivir is investigational and is available as compassionate use for severe influenza in hospitalized adults or children.

Peramivir (Rapivab)

Neuraminidase inhibitor. It is indicated for treatment of acute uncomplicated influenza in patients aged 2 years or older who have been symptomatic for less than 2 days. Peramivir is used in hospitalized patients and administered as an IV infusion.


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