Which medications in the drug class Uricosuric Agents are used in the treatment of Avian Influenza (Bird Flu)?

Updated: Apr 08, 2019
  • Author: Nicholas John Bennett, MBBCh, PhD, MA(Cantab), FAAP; Chief Editor: Michael Stuart Bronze, MD  more...
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Answer

Uricosuric Agents

Agents that inhibit the tubular secretion of the active metabolite of the drug may be used as adjunctive therapy.

Probenecid

Inhibits tubular secretion of the active metabolite of oseltamivir, reducing the clearance by approximately 50%. Systemic exposure to oseltamivir is approximately doubled.The appropriate dosing for combination therapy using probenecid and oseltamivir in the treatment of avian influenza has not been established.


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