How is avian influenza prevented?

Updated: Feb 12, 2020
  • Author: Nicholas John Bennett, MBBCh, PhD, MA(Cantab), FAAP; Chief Editor: Michael Stuart Bronze, MD  more...
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No vaccine is currently available to the public for routine immunization, although two adjuvanted influenza A (H5N1) monovalent vaccines have been approved by the FDA for H5N1 influenza A.

The AS03 adjuvant vaccine (GlaxoSmithKline) is a 2-component monovalent vaccine. It is supplied as a vial of inactivated, split-virion, A/H5N1 influenza antigen suspension and a vial of AS03 adjuvant emulsion that must be combined before IM administration. Each 0.5-mL dose contains 3.75 mcg hemagglutinin (HA) of the influenza virus strain A/Indonesia/05/2005 (H5N1). [16]

The MF59 adjuvant (Audenz; Seqirus Inc) is a ready-to-use emulsion. Each 0.5-mL dose contains 7.5 mcg HA of the H5N1 influenza virus strain A/turkey/Turkey/1/2005. [17]

Each vaccine is approved for patients aged 6 months or older and is administered as a 2-dose series given at least 21 days apart.

Prophylactic antivirals are not indicated for patients who plan to travel to areas where avian influenza has been reported. Travelers who plan to travel to areas of the world affected by avian influenza outbreaks in birds and/or humans are advised to avoid close contact with poultry, especially diseased or dead birds, and to consume only adequately cooked meat. If contact with birds in enclosed spaces is unavoidable, an N-95 respirator mask (or equivalent), gloves, and goggles should be used to minimize contact with droplets or particulates. details more specific travel recommendations.

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