What are the ONS treatment guidelines for chemotherapy-induced peripheral neuropathy (CIPN)?

Updated: Nov 04, 2020
  • Author: Alexandre Chan, PharmD, MPH, FCCP, BCPS (AQ-ID), BCOP; more...
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The ONS guidelines include the following recommendations for treatment of chemotherapy-induced peripheral neuropathy [3] :

  • Duloxetine is likely to be effective
  • Lamotrigine is unlikely to be effective
  • Carnitine/L-carnitine and human leukemia inhibitory factor are not recommended

In addition, the ONS guidelines note that the effectiveness of the following treatments could not be determined:

  • Acupuncture
  • Alpha lipoic acid
  • Amifostine
  • Amitriptyline
  • Bee venom
  • Calcium and magnesium infusion
  • Calcium channel blockers
  • Cannabis/cannabinoids
  • Carbamazepine
  • Cutaneous stimulation
  • Gabapentin and opioid combination
  • Gabapentin monotherapy
  • Glutamine
  • Glutathione
  • Goshajinkigan
  • KRN5500
  • Nortriptyline
  • Omega-3 fatty acids (eicosapentaenoic acid and others)
  • Palmitoylethanolamide
  • Pregabalin
  • Topical ketamine formulations
  • Venlafaxine
  • Vitamin E

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