What are the ASCO treatment guidelines for chemotherapy-induced peripheral neuropathy (CIPN)?

Updated: Nov 04, 2020
  • Author: Alexandre Chan, PharmD, MPH, FCCP, BCPS (AQ-ID), BCOP; more...
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The ASCO guidelines recommend duloxetine to treat painful CIPN. The guidelines advise that outside the context of a clinical trial, no recommendations can be made on the use of the following for the treatment of CIPN:

  • Exercise therapy
  • Acupuncture
  • Scrambler therapy
  • Gabapentin/pregabalin
  • Topical gel treatment containing baclofen, amitriptyline HCL, plus/minus ketamine
  • Tricyclic antidepressants
  • Oral cannabinoids

ASCO notes that although preliminary evidence suggests that exercise, acupuncture, and scrambler therapy offer potential benefit, larger sample-sized definitive studies are needed to confirm efficacy and clarify risks.

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