What is the 2007 TNM classification system of the ISCL/EORTC for cutaneous B-cell lymphomas (CBCL) of non-Hodgkin lymphoma (NHL)?

Updated: Jun 12, 2019
  • Author: Priyank P Patel, MD; Chief Editor: Emmanuel C Besa, MD  more...
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Answer

Answer

The 2007 TNM classification system of the ISCL/EORTC is used for staging, as shown in Table 3, below. [25]

Table 3. International Society for Cutaneous Lymphoma/European Organization for Research and Treatment of Cancer tumor-node-metastasis classification for cutaneous B-cell lymphoma (Open Table in a new window)

Tumor

Involvement

Node

Involvement

Metastatic Spread

Involvement

T1

Solitary skin involvement

T1a:  ≤5 cm diameter

T1b:  >5 cm diameter

N0

No lymph node involvement

M0

No evidence of extracutaneous non-lymph node disease

T2

Multiple lesions limited to one body region or two contiguous body regions

T2a: all-disease in a < 15-cm diameter

T2b: all-disease in a >15- and < 30-cm diameter

T2c: all-disease in a >30-cm diameter

N1

Involvement of one peripheral lymph node region

M1

Evidence of extracutaneous non-lymph node disease

T3

Generalized skin involvement

T3a: multiple lesions involving two noncontiguous body regions

T3b: multiple lesions involving three body regions

N2

Involvement of two or more peripheral lymph node regions or involvement of any lymph node region that does not drain an area of current or prior skin involvement

   
   

N3

Central lymph nodes involvement

   

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