What are the NCCN recommendations for the diagnostic workup of cutaneous B-cell lymphomas (CBCL) in non-Hodgkin lymphoma (NHL)?

Updated: Jun 12, 2019
  • Author: Priyank P Patel, MD; Chief Editor: Emmanuel C Besa, MD  more...
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Answer

Answer

In addition to its general guidance on diagnosis of lymphoma, the NCCN recommends the following studies to establish a diagnosis of CBCL [24] :

  • Immunohistochemistry (IHC) panel: CD20, CD3, CD5, CD10, BCL2, BCL6, IRF4/MUM1

  • Additional IHC panel for subtyping: Ki-67, CD43, CD21, CD23, Cyclin D1, kappa/lambda

  • Assessment of IgM and IgD expression to distinguish between PC-FCL and PC-DLBCL, leg type

  • Fluorescence in situ hybridization (FISH) or cytogenetics for detection of t(14;18)

  • Bone marrow biopsy in PC-FCL, optional for PC-MZL


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