What studies are recommended by the NCCN to establish a diagnosis of the Burkitt lymphoma form of non-Hodgkin lymphoma (NHL)?

Updated: Jun 12, 2019
  • Author: Priyank P Patel, MD; Chief Editor: Emmanuel C Besa, MD  more...
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Answer

Answer

In addition to its general guidance on diagnosis of lymphoma, the National Comprehensive Cancer Network (NCCN) recommends the following studies to establish a diagnosis of Burkitt lymphoma [1] :

  • Immunohistochemistry panel: CD45(LCA), CD20, CD3, BCL2, BCL6, Ki-67, TdT or

  • Cell surface marker analysis by flow cytometry: kappa/lambda, CD45, CD20, CD3, CD5, CD19, CD10, TdT

  • Fluorescence in situ hybridization (FISH) or cytogenetics for detection of t(8;14), MYC.

  • Epstein-Barr encoding region in situ hybridization (EBER-ISH) can be used to identify EBV


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