What are the variants of the Burkitt lymphoma (BL) form of non-Hodgkin lymphoma (NHL) identified by the 2008 WHO classification?

Updated: Jun 12, 2019
  • Author: Priyank P Patel, MD; Chief Editor: Emmanuel C Besa, MD  more...
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Answer

Answer

The 2008 World Health Organization classification identifies the following three clinical variants of Burkitt lymphoma (BL) [5] :

  • Endemic (eBL) – The most common form of childhood malignancy in equatorial Africa, associated with Epstein-Barr virus (EBV) infection

  • Sporadic (sBL) – The majority of cases are in the United States and Europe; up to 30% are associated with EBV

  • Immunodeficiency associated – Occurs in patients with HIV infection, post-transplantation immunosuppression, and congenital immunodeficiency


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