What are the GELF criteria for identifying which patients with non-Hodgkin lymphoma (NHL) need immediate therapy?

Updated: Jun 12, 2019
  • Author: Priyank P Patel, MD; Chief Editor: Emmanuel C Besa, MD  more...
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Answer

Answer

The Groupe d’Etude des Lymphomes Folliculaires (GELF) recommends the following criteria for identifying patients in whom immediate therapy is necessary [14] :

  • Three nodes in three distinct areas, with each node ≥3 cm in diameter

  • A tumor ≥7 cm in diameter

  • Presence of systemic symptoms

  • Symptomatic spleen enlargement

  • Ascites or pleural effusion

  • Cytopenias (leukocytes < 1.0 x 109/L and/or platelets < 100 x 109/L)

  • Leukemia (>5.0 x 109/L malignant cells)


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