What are the NCCN treatment guidelines for stage IV/metastatic soft tissue sarcoma (STS) of the extremities, superficial trunk, or head and neck?

Updated: Sep 02, 2018
  • Author: Steven C Katz, MD, FACS; Chief Editor: Edwin Choy, MD, PhD  more...
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Answer

Answer

NCCN treatment recommendations for stage IV/metastatic disease and unresectable disease are as follows [1] :

  • Patients should be referred to a multidisciplinary team with extensive experience in the treatment of STS.
  • Treatment options should be based on performance status, patient preferences, specific clinical problems from the metastases and treatment availability.
  • Enrollment in a clinical trial is recommended.
  • For patients with single-organ or resectable stage IV disease, metastasectomy may be considered in conjunction with preoperative or postoperative chemotherapy with or without radiation. Ablative and intra-arterial modalities may be considered, depending on disease anatomy and burden.
  • Symptomatic patients with disseminated disease may be treated with palliative measures, including radiation, surgery, or chemotherapy.

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