What are the challenges to establishing treatment guidelines for soft tissue sarcoma (STS)?

Updated: Sep 02, 2018
  • Author: Steven C Katz, MD, FACS; Chief Editor: Edwin Choy, MD, PhD  more...
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The consideration of soft tissue sarcoma (STS) as a single entity is a matter of necessity to enable clinical study of these exceedingly rare diseases. Their wide range of natural history and biologic behavior makes it exceedingly difficult to establish management guidelines that account for the nuances of individual clinical presentations. With over 50 distinct histologic subtypes, STS requires physicians to adapt guidelines to fit the clinical features of each patient’s disease. However, certain principles serve as cornerstones for multimodality management of STS when applied in the context of a highly individualized patient and tumor assessment.

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