What are the guidelines on classification of bone sarcoma?

Updated: Jul 01, 2020
  • Author: Mrinal M Gounder, MD; Chief Editor: Edwin Choy, MD, PhD  more...
  • Print
Answer

Answer

ESMO-PaedCan-EURACAN guidelines recommend specifying the tumor type and subtype according to the 2013 World Health Organization (WHO) classification. [2] Under the WHO classification system, tumors are further classified as benign, intermediate or malignant. Bone sarcomas are classified by group (eg, chondrogenic, osteogenic, fibrohistiocytic, Ewing sarcoma) and further subtyped within each group. The most common pathologic subtype is conventional central osteosarcoma. [3]

NCCN guidelines recommend that the final pathologic evaluation include assessment of surgical margins as well as the size/dimensions of tumors. [1]

With patients who present with locally advanced or metastatic chondrosarcoma, chordoma, or osteosarcoma, physicians should discuss the options surrounding deep-sequencing genomic tests, which may identify mutations that may be responsive to specific therapies and thus may guide referral to clinical trials. Use of these tests is not part of current NCCN guidelines, but is increasingly part of oncologic practice. A further barrier is that even when available, these tests are typically not reimbursed by private or government insurance.


Did this answer your question?
Additional feedback? (Optional)
Thank you for your feedback!