How are gastropancreatic neuroendocrine tumors (NETs) graded?

Updated: Dec 23, 2018
  • Author: Evan S Ong, MD, MS; more...
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Answer

Answer

Grading schemes for neuroendocrine tumors (NETs) use mitotic count; the level of the nuclear protein Ki-67, which is associated with cellular proliferation; and assessment of necrosis. The World Health Organization (WHO) and the European Neuroendocrine Tumor Society (ENETS)  both incorporate mitotic count and Ki-67 proliferation for the classification of gastroenteropancreatic NETs (GEP-NETs). [1, 2, 3]

Tumors fall into one of the following three grades:

  • G1: Well differentiated, low grade
  • G2: Well differentiated, intermediate grade
  • G3: Poorly differentiated, high grade

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