What are the NCCN criteria for the evaluation of Lynch syndrome (LS)?

Updated: Apr 10, 2020
  • Author: Elwyn C Cabebe, MD; Chief Editor: N Joseph Espat, MD, MS, FACS  more...
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Answer

Answer

Th NCCN criteria for the evaluation of Lynch syndrome (LS) include the following [8] :

  • Known LS pathogenic variant in family
  • Personal history of colorectal, endometrial, or other LS-associated cancer
  • Family history of a first-degree relative with colorectal or endometrial cancer diagnosed before age 50
  • Family history of a first-degree relative with colorectal or endometrial cancer and another synchronous or metachronous LS-related cancer
  • Family history of 2 or more first-degree or second-degree relatives with LS-related cancer, including 1 or more diagnosed before age 50
  • Family history of 3 or more first-degree or second-degree relatives with LS-related cancers

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