What are NCCN criteria for the evaluation of high-risk syndromes in colorectal cancer screening?

Updated: Oct 08, 2019
  • Author: Elwyn C Cabebe, MD; Chief Editor: N Joseph Espat, MD, MS, FACS  more...
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Individuals meeting one or more of the following criteria should receive further evaluation for high-risk syndromes:

  • Individuals meeting the revised Bethesda Guidelines (Lynch Syndrome)
  • Family members meeting Amsterdam criteria (Lynch Syndrome)
  • Individuals with more than 10 adenomas detected ( MUTYH)
  • Individuals with multiple GI hamartomatous polyps (PJS and JPS)
  • Family members with a known high-risk syndrome associated with colorectal cancer, with or without a known mutation
  • Individuals with a desmoid tumor

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