What are the NCCN criteria for increased or high-risk individuals for colorectal cancer screening?

Updated: Oct 08, 2019
  • Author: Elwyn C Cabebe, MD; Chief Editor: N Joseph Espat, MD, MS, FACS  more...
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The NCCN guidelines provide screening recommendations for patients at increased risk due to any of the following [7] :

  • Personal history of adenoma or sessile serrated polyp
  • Personal history of colorectal cancer
  • Inflammatory bowel disease
  • Positive family history

The guidelines also specify recommendations for patients with the following high-risk syndromes [8] :

  • Lynch syndrome (hereditary nonpolyposis colorectal cancer)
  • Classic familial adenomatous polyposis (FAP)
  • Attenuated familial adenomatous polyposis (AFAP)
  • MUTHYH-associated polyposis
  • Peutz-Jeghers syndrome (PJS)
  • Juvenile polyposis syndrome (JPS)
  • Serrated polyposis syndrome (SPS)
  • Colonic adenomatous polyposis of unknown etiology
  • Cowden syndrome/PTEN hamartoma tumor syndrome
  • Li-Fraumeni syndrome

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