What are the US Multi-Society Task Force on Colorectal Cancer guidelines for intervals of subsequent colorectal cancer screening?

Updated: Mar 18, 2021
  • Author: Elwyn C Cabebe, MD; Chief Editor: N Joseph Espat, MD, MS, FACS  more...
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Suggested timing of initial screening and intervals for subsequent testing for different risk populations are as follows:

  • For patients at average risk, testing with a tier 1 test should begin at age 45 years for African Americans and at age 50 for patients of all other races.
  • For patients with a family history of colorectal cancer or advanced adenoma that was diagnosed before age 60 years in one first-degree relative or at any age in two first-degree relatives, testing should begain with colonoscopy at an age10 years younger than the youngest age at diagnosis of a first-degree relative, or age 40, to be repeated every 5 years.

  • In patients with one first-degree relative with colorectal cancer, advanced adenoma, or an advanced serrated lesion diagnosed at age 60 or older, screening should begin with a tier 1 test at age 40 and continue at the same intervals as inaverage-risk patients.

  • Colonoscopy screening should be discontinued in patients aged 75 or older with prior negative screening tests or whose life expectancy is less than 10 years, or in those 85 years or older without prior screening.

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