What are correlated factors of lumbar disc disease?

Updated: Sep 25, 2018
  • Author: Kamran Sahrakar, MD, FACS; Chief Editor: Brian H Kopell, MD  more...
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Answer

Correlations have been found with the following [15] :

  • Body mass index, mechanical loading, and genetic predisposition.
  • Genes coding for collagen, aggrecan, vitamin D receptors, matrix metalloproteinase, cartilage intermediate layer protein, and interleukins.
  • Smoking and increased rates of disk degeneration, with animal models showing increased proinflammatory markers, alterations to annular structure, vasoconstriction, and altered nutrient distribution to the disc.

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