Which histologic findings are characteristic of contrast-induced nephropathy (CIN)?

Updated: Dec 18, 2018
  • Author: Anita Basu, MD, FACP; Chief Editor: Vecihi Batuman, MD, FASN  more...
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Answer

Contrast media cause direct toxic effects on renal tubular epithelial cells, characterized by cell vacuolization, interstitial inflammation, and cellular necrosis. In one study, these characteristic changes, called osmotic nephrosis, were observed in 22.3% of patients undergoing renal biopsy within 10 days after contrast exposure. [30]


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