What medications are used in the treatment of syndrome of inappropriate antidiuretic hormone secretion (SIADH)?

Updated: Aug 16, 2019
  • Author: Christie P Thomas, MBBS, FRCP, FASN, FAHA; Chief Editor: Vecihi Batuman, MD, FASN  more...
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Answer

Vasopressin receptor antagonists inhibit the V2 receptor, reducing the number of aquaporin-2 water channels in the renal collecting duct and decreasing the water permeability of the collecting duct.

The use of a combination of a loop diuretic (eg, furosemide) and the replacement of urine output with a solution that contains a higher Na+ concentration (ie, 3% sodium chloride solution) can be dramatically successful in some patients. Concomitant use of furosemide increases free water excretion relative to Na+ excretion by the kidneys, thus correcting fluid expansion induced by hypertonic sodium chloride solution.


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