What other causes of euvolemia should be excluded before a diagnosis of syndrome of inappropriate antidiuretic hormone secretion (SIADH) is made?

Updated: Aug 16, 2019
  • Author: Christie P Thomas, MBBS, FRCP, FASN, FAHA; Chief Editor: Vecihi Batuman, MD, FASN  more...
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Answer

The presence of peripheral edema with elevated jugular venous pressure, pulmonary rales, or ascites indicates increased volume. This may be seen in conditions such as heart failure or cirrhosis (with other signs of liver failure).

In euvolemic states, before attributing the hyponatremia to SIADH, renal disease and endocrine disorders such thyroid, pituitary, and adrenal insufficiency should be excluded.


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