How does syndrome of inappropriate antidiuretic hormone secretion (SIADH) affect serum potassium levels?

Updated: Aug 16, 2019
  • Author: Christie P Thomas, MBBS, FRCP, FASN, FAHA; Chief Editor: Vecihi Batuman, MD, FASN  more...
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Answer

Serum potassium concentration generally remains unchanged. Movement of potassium from the intracellular space to the extracellular space prevents dilutional hypokalemia. As hydrogen ions move intracellularly, they are exchanged for potassium in order to maintain electroneutrality.

If both hypokalemia and metabolic alkalosis are present, consider diuretic therapy or vomiting as the cause of hyponatremia. If hyperkalemia and metabolic acidosis coexist with hyponatremia, consider adrenal insufficiency and volume depletion leading to acute kidney injury.


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