What factors can modulate urine Na+ concentration in persons with syndrome of inappropriate antidiuretic hormone secretion (SIADH)?

Updated: Aug 16, 2019
  • Author: Christie P Thomas, MBBS, FRCP, FASN, FAHA; Chief Editor: Vecihi Batuman, MD, FASN  more...
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Answer

Urine Na+ concentration in persons with SIADH is usually more than 40 mEq/L because, in SIADH, Na+ handling is not abnormal and the urine Na+ concentration reflects Na+ intake, which is generally more than 40 mEq/d (usually 50-100 mEq/d). However, the urine Na+ concentration in persons with SIADH can be modulated by dietary Na+ intake. Thus, on a low-Na+ diet, patients with SIADH may have a urine Na+ level of less than 40 mEq/L.


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