What other conditions associated with hypervolemia should be considered in the differential diagnoses of syndrome of inappropriate antidiuretic hormone secretion (SIADH)?

Updated: Aug 16, 2019
  • Author: Christie P Thomas, MBBS, FRCP, FASN, FAHA; Chief Editor: Vecihi Batuman, MD, FASN  more...
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Answer

Other conditions to consider in the differential diagnosis of hyponatremia are those that are associated with hypervolemia in which the baroreceptors perceive reduced effective circulating volume and stimulate AVP secretion. These conditions include congestive heart failure, cirrhosis, and nephrotic syndrome. These should be evident on clinical examination because of the presence of peripheral edema with elevated jugular venous pressure, pulmonary rales, ascites, or stigmata of advanced liver disease.


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