What is nephrogenic syndrome of inappropriate antidiuresis (NSIAD)?

Updated: Aug 16, 2019
  • Author: Christie P Thomas, MBBS, FRCP, FASN, FAHA; Chief Editor: Vecihi Batuman, MD, FASN  more...
  • Print
Answer

NSIAD is a rare X-linked recessive genetic disease arising from gain-of-function mutations in the V2 receptor, resulting in a spontaneously active receptor and unregulated water reabsorption. The laboratory features are identical to those of SIADH, with euvolemic hyponatremia, plasma hypo-osmolality, and increased urinary osmolality. The disease is likely to present in early infancy, although some adults have been described with this disorder. [26, 27] If AVP levels are measured, they are predicted to be low.


Did this answer your question?
Additional feedback? (Optional)
Thank you for your feedback!