Does a decreasing serum Na+ concentration during pregnancy require treatment?

Updated: Aug 16, 2019
  • Author: Christie P Thomas, MBBS, FRCP, FASN, FAHA; Chief Editor: Vecihi Batuman, MD, FASN  more...
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The reset osmostat has been observed in pregnant women. Increased human chorionic gonadotropin levels have been implicated in this condition. The serum Na+ concentration falls by approximately 5 mEq/L in the first 2 months of pregnancy and remains stable until after delivery, when it returns to normal levels. Recognizing this entity is important because it does not require treatment.

Psychogenic polydipsia

This condition is characterized by an increase in water intake attributed to a defect in the thirst mechanism. In some patients, the osmotic threshold for thirst is reset below the reset for release of ADH. This disorder is mostly observed in patients with psychosis.

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