Which drugs induce syndrome of inappropriate antidiuretic hormone secretion (SIADH) via an unknown mechanism?

Updated: Aug 16, 2019
  • Author: Christie P Thomas, MBBS, FRCP, FASN, FAHA; Chief Editor: Vecihi Batuman, MD, FASN  more...
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Answer

Drugs with an uncertain mechanism are as follows:

  • Antineoplastic agents – Cisplatin, melphalan, methotrexate, imatinib

  • Ciprofloxacin

  • Clomipramine

  • 3,4-methylenedioxymethamphetamine (MDMA; ecstasy)

  • Phenoxybenzamine

  • Antiepilepsy drugs – Sodium valproate, lamotrigine, levetiracetam, gabapentin

  • Selective serotonin reuptake inhibitors (SSRIs; eg, sertraline, fluoxetine, paroxetine)

  • Thiothixene


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