Which drugs may induce syndrome of inappropriate antidiuretic hormone secretion (SIADH) by stimulating arginine vasopressin (AVP) release?

Updated: Aug 16, 2019
  • Author: Christie P Thomas, MBBS, FRCP, FASN, FAHA; Chief Editor: Vecihi Batuman, MD, FASN  more...
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Answer

Drugs that stimulate AVP release are as follows:

  • Acetylcholine

  • Antineoplastic agents - Adenine arabinoside, cyclophosphamide, ifosfamide, vincristine, vinblastine

  • Barbiturates

  • Bromocriptine

  • Carbachol

  • Chlorpropamide

  • Clofibrate

  • Cyclopropane

  • Dibenzazepines (eg, carbamazepine, oxcarbazepine)

  • Halothane

  • Haloperidol

  • Histamine

  • Isoproterenol

  • Lorcainide

  • Opiates (eg, morphine)

  • Nicotine (inhaled tobacco)

  • Nitrous oxide

  • Phenothiazines (eg, thioridazine)

  • Thiopental

  • Monoamine oxidase inhibitors (eg, tranylcypromine)

  • Tricyclic antidepressants (eg, amitriptyline, desipramine)


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