How is arginine vasopressin (AVP) synthesized?

Updated: Aug 16, 2019
  • Author: Christie P Thomas, MBBS, FRCP, FASN, FAHA; Chief Editor: Vecihi Batuman, MD, FASN  more...
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Answer

AVP is an nonapeptide similar in structure to oxytocin. AVP is synthesized in the cell bodies of neurons in the supraoptic and paraventricular nuclei of the anterior hypothalamus as a precursor protein, the vasopressin-neurophysin 2–copeptin preprotein, which travels along the supraopticohypophyseal tract into the posterior pituitary. There, the preprotein is cleaved to AVP, neurophysin 2 and co-peptin and stored in secretory granules in association with a carrier protein, neurophysin, in the terminal dilatations of secretory neurons that rest against blood vessels. [4]


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