What is the Bartter-Schwartz criteria for confirming a diagnosis of syndrome of inappropriate antidiuretic hormone secretion (SIADH)?

Updated: Aug 16, 2019
  • Author: Christie P Thomas, MBBS, FRCP, FASN, FAHA; Chief Editor: Vecihi Batuman, MD, FASN  more...
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Answer

In the absence of a single laboratory test to confirm the diagnosis, SIADH is best defined by the classic Bartter-Schwartz criteria, which can be summarized as follows [2] :

  • Hyponatremia with corresponding hypo-osmolality

  • Continued renal excretion of sodium

  • Urine less than maximally dilute

  • Absence of clinical evidence of volume depletion

  • Absence of other causes of hyponatremia

  • Correction of hyponatremia by fluid restriction


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