What physical findings of severe or rapid-onset hyponatremia may be seen in syndrome of inappropriate antidiuretic hormone secretion (SIADH)?

Updated: Aug 16, 2019
  • Author: Christie P Thomas, MBBS, FRCP, FASN, FAHA; Chief Editor: Vecihi Batuman, MD, FASN  more...
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Answer

After the identification of hyponatremia, the approach to the patient depends on the clinically assessed volume status. Prominent physical findings may be seen only in severe or rapid-onset hyponatremia and can include the following:

  • Confusion, disorientation, delirium

  • Generalized muscle weakness, myoclonus, tremor, asterixis, hyporeflexia, ataxia, dysarthria, Cheyne-Stokes respiration, pathologic reflexes

  • Generalized seizures, coma

See Presentation for more detail.


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