What is the role of kidney transplantation in beta-2-microglobulin (beta-2m) amyloidosis treatment?

Updated: Nov 14, 2019
  • Author: Anita Basu, MD, FACP; Chief Editor: Vecihi Batuman, MD, FASN  more...
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Answer

Kidney transplantation is the treatment of choice for beta-2m amyloidosis. It lowers the blood concentration of beta-2m to the reference range, halting the progression of the disease.

Osteoarticular symptoms, such as joint pain, swelling, and stiffness, disappear within the first week after transplantation. Cystic lesions usually remain unchanged, and regression of amyloid deposits probably does not occur.

Transplantation is not an option for all patients. Some patients on long-term dialysis will have undergone unsuccessful kidney transplantation before they first developed beta-2m amyloidosis; in certain other cases, patients are not suitable candidates.


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