What are the signs and symptoms of carpal tunnel syndrome in beta-2-microglobulin (beta-2m) amyloidosis?

Updated: Nov 14, 2019
  • Author: Anita Basu, MD, FACP; Chief Editor: Vecihi Batuman, MD, FASN  more...
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Answer

This syndrome is the most common presenting feature. It usually is bilateral and progressive. [11] Patients report numbness, paresthesias, pain, and swelling in the region of the distal median nerve. Pain usually is worse during dialysis and at night. Progression to contraction of the hand and atrophy of the muscles can occur. However, it is important to remember that not all cases of carpal tunnel syndrome in dialysis patients are amyloid related; the syndrome may arise from other causes, such as ischemia.


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