Which clinical history findings are characteristic of beta-2-microglobulin (beta-2m) amyloidosis?

Updated: Nov 14, 2019
  • Author: Anita Basu, MD, FACP; Chief Editor: Vecihi Batuman, MD, FASN  more...
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Answer

Clinical manifestations of beta-2m amyloidosis almost never appear before a patient has undergone 5 years of dialysis therapy. Unlike other types of amyloids, beta-2m amyloid is confined largely to osteoarticular sites. [12]

Patients often present with a characteristic triad of carpal tunnel syndrome, shoulder pain, and flexor tenosynovitis in the hands. The rate of surgery for osteoarticular disorders, such as carpal tunnel syndrome, destructive spondyloarthropathy (DSA), and joint arthropathy, which may show the presence of dialysis-related amyloidosis (DRA), is very high. [13]

Visceral deposits are rare, occur after 10 or more years of dialysis, and tend not to cause symptoms in most cases.


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