What is the role of dialysis in the etiology of beta-2-microglobulin (beta-2m) amyloidosis?

Updated: Nov 14, 2019
  • Author: Anita Basu, MD, FACP; Chief Editor: Vecihi Batuman, MD, FASN  more...
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Answer

Retention of amyloidogenic protein remains a key factor in patients on dialysis. Several factors affecting retention have been implicated, including the following:

  • Type of dialysis membrane
  • Prolonged uremic state and/or decreased diuresis
  • Elevated levels of cytokines
  • Advanced glycation end products
  • Dialysate

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