Which medications in the drug class Alpha Blockers, Antihypertensives are used in the treatment of Renovascular Hypertension?

Updated: Dec 01, 2020
  • Author: Rebecca J Schmidt, DO, FACP, FASN; Chief Editor: Vecihi Batuman, MD, FASN  more...
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Alpha Blockers, Antihypertensives

At low doses, alpha-adrenergic receptor blockers may be used as monotherapy in the treatment of hypertension. At higher doses, they may cause sodium and fluid to accumulate. As a result, concurrent diuretic therapy may be required to maintain the hypotensive effects of alpha-receptor blockers.


Phentolamine is an alpha1- and alpha2-adrenergic blocking agent that antagonizes the action of circulating epinephrine and norepinephrine, reducing the hypertension that results from catecholamine's effects on the alpha-receptors.

Phenoxybenzamine (Dibenzyline)

Phenoxybenzamine is a noncompetitive alpha-adrenergic blocker. It is a long-acting adrenergic alpha-receptor blocker that can produce and maintain a chemical sympathectomy. Phenoxybenzamine hydrochloride lowers supine and upright blood pressure. It does not affect the parasympathetic nervous system.

Prazosin (Minipress)

Prazosin is an alpha blocker. It decreases arterial tone by allowing peripheral postsynaptic blockade.

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