What is the difference in prognosis for ADPKD1 and ADPKD2?

Updated: Mar 24, 2020
  • Author: Roser Torra, MD, PhD; Chief Editor: Vecihi Batuman, MD, FASN  more...
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Answer

Although the 2 forms of ADPKD, ADPKD1 and ADPKD2, share similar clinical features, renal prognosis is strikingly different. [22, 23] ADPKD2 is a milder disease, based on the age of onset of ESRD. The median age of renal survival for individuals with ADPKD1 is 56 years, compared with 68 years in those with ADPKD2. Although ADPKD2 is milder than ADPKD1, it has an overall impact on survival and shortens life expectancy.


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