What is included in the treatment of autosomal dominant polycystic kidney disease (ADPKD)?

Updated: Mar 24, 2020
  • Author: Roser Torra, MD, PhD; Chief Editor: Vecihi Batuman, MD, FASN  more...
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Answer

Management of ADPKD includes the following:

  • Control blood pressure: Drugs of choice are ACEIs (eg, captopril, enalapril, lisinopril) or ARBs (eg, valsartan, telmisartan, losartan, irbesartan, candesartan, olmesartan)
  • Control abnormalities related to renal failure: Drugs to maintain electrolyte levels (eg, calcium carbonate, calcium acetate, sevelamer, lanthanum carbonate, calcitriol [possibly], diuretics, blood pressure medications)
  • Treat UTIs
  • Treat cyst infections: Gyrase inhibitors (eg, ciprofloxacin, chloramphenicol, clindamycin, levofloxacin); dihydrofolic acid inhibitors (TMX/SMP)
  • Treat hematuria: Possibly analgesic plus copious oral hydration
  • Reduce abdominal pain produced by enlarged kidneys
  • Prevent cardiac valve infection in patients with intrinsic valve disease
  • Reduce kidney function decline in adults at risk of rapidly progressive ADPKD (tolvaptan [Jynarque])

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