Which medications in the drug class Immunosuppressant agents are used in the treatment of Minimal-Change Disease?

Updated: Jan 05, 2021
  • Author: Abeera Mansur, MD; Chief Editor: Vecihi Batuman, MD, FASN  more...
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Immunosuppressant agents

For remission of nephrotic syndrome.

Cyclosporine A (Sandimmune, Neoral)

Inhibits production and release of IL-2, leading to inhibition of IL-2–mediated activation of T lymphocytes.

Chlorambucil (Leukeran)

To induce remission of proteinuria. Interferes with DNA replication and RNA transcription.

Tacrolimus (Astagraf XL, Envarsus XR, Hecoria)

Calcineurin inhibitor; inhibits T-cell activation and proliferation, humoral immunity.

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