What causes minimal-change disease (MCD)?

Updated: Jan 05, 2021
  • Author: Abeera Mansur, MD; Chief Editor: Vecihi Batuman, MD, FASN  more...
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Almost all cases are idiopathic, but a small percentage of cases (approximately 10-20%) may have an identifiable cause. Secondary cases may be due to any of the following:

  • Drugs - Nonsteroidal anti-inflammatory drugs (NSAIDs), rifampin, interferon, ampicillin/penicillin, trimethadione, mercury-containing cosmetic skin cream

  • Toxins - Mercury, [12] lithium, bee stings, fire coral exposure [13]

  • Infection - Infectious mononucleosis, HIV, immunization

  • Tumor - Hodgkin lymphoma [14] (most commonly), carcinoma, other lymphoproliferative diseases

  • Hematopoietic stem cell transplantation [15]

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