How is syndrome of apparent mineralocorticoid excess (AME) diagnosed in the workup of metabolic alkalosis?

Updated: Dec 10, 2020
  • Author: Christie P Thomas, MBBS, FRCP, FASN, FAHA; Chief Editor: Vecihi Batuman, MD, FASN  more...
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Answer

Measurement of urine cortisol metabolites is used to diagnose the syndrome of apparent mineralocorticoid excess (AME). In AME and other conditions of 11B-HSD deficiency, the proportion of cortisol to cortisone metabolites is increased (ie, ratio of tetrahydrocortisol and 5-alpha-tetrahydrocortisol to tetrahydrocortisone).


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