Which medications in the drug class Alkalinizing Agents are used in the treatment of Metabolic Acidosis?

Updated: Oct 10, 2018
  • Author: Christie P Thomas, MBBS, FRCP, FASN, FAHA; Chief Editor: Vecihi Batuman, MD, FASN  more...
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Answer

Alkalinizing Agents

Acute metabolic acidosis is usually treated with alkali therapy to raise plasma pH and to maintain it at greater than 7.20.

Sodium bicarbonate

Sodium bicarbonate is a systemic and urinary alkalinizer used to increase serum or urinary HCO3- concentration and raise pH. Dosing is based on the clinical setting, blood pH, serum HCO3- level, and PaCO2.

Tromethamine (THAM)

THAM combines with hydrogen ions to form a bicarbonate buffer. It is used to prevent and correct systemic acidosis. It is available as 0.3-mol/L IV solution containing 18 g (150 mEq) per 500 mL (0.3 mEq/mL).


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