How is methanol or ethylene glycol poisoning treated in patients with metabolic acidosis?

Updated: Oct 10, 2018
  • Author: Christie P Thomas, MBBS, FRCP, FASN, FAHA; Chief Editor: Vecihi Batuman, MD, FASN  more...
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Answer

Treatment should be started promptly to prevent any neurologic sequelae.

Fomepizole (4-methylpyrazole; Antizol) is a potent inhibitor of alcohol dehydrogenase and is now the preferred therapy, although it is much more expensive than ethanol. Fomepizole is given as a loading dose and continued over several doses until toxin levels decline substantially. Fomepizole levels do not need to be monitored.


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