Which agent is most frequently used to correct chronic metabolic acidosis in patients with chronic kidney disease (CKD)?

Updated: Oct 10, 2018
  • Author: Christie P Thomas, MBBS, FRCP, FASN, FAHA; Chief Editor: Vecihi Batuman, MD, FASN  more...
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NaHCO3 is the most frequently used agent. It is administered in an amount necessary to keep the serum HCO3- level greater than 20 mEq/L. The average requirement is approximately 1-2 mEq/kg/d. Sodium citrate should be avoided if the patient is taking aluminum as a phosphate binder, because citrate increases aluminum absorption and, hence, the risk for aluminum toxicity.

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