How is type 2 renal tubular acidosis (RTA) corrected?

Updated: Oct 10, 2018
  • Author: Christie P Thomas, MBBS, FRCP, FASN, FAHA; Chief Editor: Vecihi Batuman, MD, FASN  more...
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Answer

Correcting this form of acidosis with alkali is difficult because a substantial proportion of the administered HCO3- is excreted in the urine, and large amounts are needed to correct the acidosis (10-30 mEq/kg/d). Potassium is also required when administering HCO3-. Correction is essential in children for normal growth, while in adults aggressive correction to a normal level may not be required. Thiazide diuretics can be administered to induce diuresis and mild volume depletion, which, in turn, raises the proximal tubule threshold for HCO3- wasting.


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